HOXA5 INHIBITS THE PROLIFERATION OF EXTRAHEPATIC CHOLANGIOCARCINOMA CELLS BY ENHANCING MXD1 EXPRESSION AND ACTIVATING THE P53 PATHWAY

HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway

Abstract Homeobox A5 (HOXA5) is a transcription factor in mammalian and can regulate cell differentiation, proliferation, and apoptosis as well as tumorigenesis.However, little is known on whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma.The methylation levels of HOXA5 were evaluated by methylation microarray and bis

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Management of post-cervical laminectomy fusion pain syndrome with a successful trial of spinal cord stimulation

Abstract.Introduction:.Spinal cord stimulation has been shown to be beneficial in various postsurgical neuropathic pain syndromes, but the macbook already small cervical epidural space due to epidural fibrosis makes cervical spinal cord stimulator placement very difficult.We present a case of successful cervical cord stimulator implantation in a pa

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Acquisition and extinction of human avoidance behavior: Attenuating effect of safety signals and associations with anxiety vulnerabilities

While avoidance behavior is often an adaptive strategy, exaggerated avoidance can be detrimental and result in the development of psychopathologies, such as anxiety disorders.A large animal literature shows that the acquisition and extinction of avoidance behavior in rodents depends on individual differences (e.g., sex, strain) and might be modulat

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Ar-Ridha min Al-e Muhammad

In this brief study, we will try to examine the motto of "Ar-Ridha min Ethernet Switch Al-e Muhammad"; the motto by whose use the Abbasids managed to secure the support of many members of the Heshemite clan and their followers, especially among Iranians, and behind which they were able to disguise their real face and identity for a long time to com

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